How can recombinant vaccines be produced in the milk of transgenic rabbits?
Rotavirus Virus-Like Particles (Rotavirus-VLP’s) are high molecular weight protein complexes consisting of hundreds of Rotavirus proteins of two types: VP2 and VP6. These proteins are derived from the Rotavirus capsid, and assemble naturally to form virus-like particles, mimicking the rotavirus structure, with the same ability to trigger the immune system but without the risk of infection. Rotavirus-VLP’s represent a very powerful antigen carrier due to their high molecular weight and the repetition of the antigen motif in each particle. Recombinant chimeric proteins can be produced with any antigen of interest (whether small or large peptide or even large functional molecules) inserted within VP2 and VP6 protein without disrupting the Rotavirus-VLP structure, in order to produce safe and effective vaccine solutions.
