How can one explain the difference in efficacy between fipronil and permethrin against ticks?
Fipronil and permethrin act on different nerve structures; furthermore, the association of imidacloprid and permethrin has been shown to be more active on ticks than permethrin used on its own. The pyrethroids in general, and permethrin in particular, because of peculiar chemical characteristics and a low melting point (which allows a vapour effect), express a powerful repellent effect which keeps arthropods away. What is more, permethrin can produce what is termed the “hot foot” effect (the parasite tries to escape from the active substance as humans do when they withdraw their feet from very hot sand). Ticks and the other arthropods which are not repelled by the repellent effect and which come into contact with the dog which has been treated detach themselves rapidly from it, and in any case the contact time is generally sufficient to kill these parasites. There are no studies demonstrating any repellent activities of fipronil. It has been shown in some comparative studies that fipro
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