How can KINAXO’s technologies help me understand my compound’s biological effects and predict its clinical outcome?
Understanding the mode of action is a key issue in any drug development program. Experience shows that the cellular interplay of a drug’s protein interactions ultimately contributes to the observed biological effects. Therefore, it is crucial to know about a drug candidate’s direct cellular target interactions before commencing costly clinical trials. Our KINAXO Cellular Target Profiling® and KinAffinity® Technologies determine a compound’s protein target profile in cells or tissue, thus reflecting the native conformation and activity of the target protein in an unbiased manner in its physiological context. As a consequence, the derived target and off-target profile supports predictions about the compound’s effects as well as side-effects on cells in vivo. This helps one understand the therapeutic potential of a drug as well as toxic side-effects.
