How can curve progression be predicted?
Because we don’t know the cause of idiopathic scoliois, curve progression prediction is not fully possible at this point in time. Studies looking at the genetics of scoliosis have identified genes that are partially responsible and now, physicians are beginning to test patients using a diagnostic test called the SCOLISCORE AIS (www.axialbiotech.com/company/find/press/2009/16). Correlations between the test results and probability of curve progression are at a fairly early stage. As more data are collected, we will understand better which individuals are likely to progress. At this point, we know that: • Curves are more likely to progress in females4. • If curves progress, they are more likely to progress during periods of growth4. • Most curves do not progress beyond 20 degrees Cobb4. • Curves that reach beyond 30 degrees Cobb are more likely to progress as adults5. This progression is probably related to mechanical forces (vicious cycle theory).
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