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How can a man have AMN if his mother/aunt/grandmother is not a carrier?

AMN aunt grandmother man mother
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How can a man have AMN if his mother/aunt/grandmother is not a carrier?

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In some unusual casesabout 5% to 7% of all cases, according to research published by the late Hugo Moser, M.D., a pioneer in ALD studiesALD arises from de novo mutationsgenetic mutations that were not present in the parents.

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