How are Symansis products different to those available from other suppliers?
Symansis’ products are expressed from human cells, rather than from E. coli, CHO or insect cells. Expression from human cells facilitates post-translational modifications (PTMs), such as phosphorylation and glycosylation of the peptide backbone. PTMs may affect protein stability, protein-protein interactions, protein folding, and antigenicity. Non-human expression systems do not add certain PTMs and may add other PTMs incorrectly (e.g. Insect cells are known to overglycosylate exogenously expressed proteins). Expressing human cytokines from human cells ensures that the proteins will more closely mimic the naturally occurring cytokines. For further information on this area please visit our Resource Centre pages.
