How are opioids taken?
Opioids are generally well-absorbed via intramuscular and subcutaneous administration, as well as at muscosal sites. Oral consumption is often accompanied by extensive first-pass metabolism making it less efficient than the aforementioned methods of delivery. Intravenous injection will provide the user with the highest bioavailablility (most of the drug will be used, if not 100%), and the most pleasurable rush. Many addicts prefer this method of administration because of the “rush” and the fact that it takes less to get high (due to the high bioavailability).
