How are infections with Cryptococcus neoformans treated?
Treatment of meningoencephalitis and other severe cryptococcal infections is usually initiated with amphotericin B, often with flucytosine. Fluconazole is used for maintenance therapy in HIV-infected patients with cryptococcal meningoencephalitis, and may be used for patients with milder forms of infection not involving the central nervous system. Guidelines for treating cryptococcal infections are available at the Infectious Diseases Society of America website.