How are genes linked to disease?
Many, if not most, diseases have their roots in our genes. Genes determine everything from how efficiently we process foods to how vigorously we respond to infections. More than 4,000 diseases are thought to stem from mutated genes inherited from at least one parent. Common disorders such as heart disease and most cancers arise from a complex interplay between multiple interacting genes (genetic susceptibility) and environmental factors. Individual susceptibility to these common disorders is often associated with prevalent DNA variations in the human genome (polymorphisms).