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How are fluorescent dyes attached to the dendrimer?

April 26, 2017attached dendrimer dyes fluorescent

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How are fluorescent dyes attached to the dendrimer?

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Fluorescent dyes are covalently attached by coupling fluorescently-labeled oligonucleotides to the free surface arms of each dendrimer. The excess labeled oligonucleotides are then removed by chromatography. Each lot of fluorescent dendrimer undergoes quality control testing using gel electrophoresis, fluorometry, and microarray performance prior to release.