How are changes in chromosome 22 related to health conditions?
GeneCards provides a table of genes on chromosome 22 and disorders related to those genes (http://www.genecards.org/cgi-bin/listdiseasecards.pl?type=chrom&search=22). Changes in the structure or number of copies of a chromosome can also cause problems with health and development. The following chromosomal conditions are associated with such changes in chromosome 22. cancers A rearrangement (translocation) of genetic material between chromosomes 9 and 22 is associated with several types of blood cancer known as leukemias. This chromosomal abnormality, which is commonly called the Philadelphia chromosome, is found only in cancer cells. It fuses part of a specific gene from chromosome 22 (the BCR gene) with part of another gene from chromosome 9 (the ABL gene). The protein produced from this fused gene abnormally signals tumor cells to continue dividing and prevents them from adequately repairing DNA damage. The Philadelphia chromosome has been identified in most cases of a slowly progres
