Haven there been many compounds discovered to date that have a positive effect on non-obese diabetic (NOD) lab mice?
For those knowledgeable in the field, there are indeed over 200 ways to “cure” mice that are not yet diabetic mice (pre-diabetic). Unfortunately, this does not represent human disease where the blood sugars are elevated and the disease firmly established. Numerous interventions applied in the pre-diabetic phase can slow or halt progression to hyperglycemia; however when the immune attack has engendered sufficient beta cell damage to result in severe hyperglycemia, few of these interventions are successful. Therefore, we believe that to produce NOD mouse data that might be translated to successful human experiments, we should use protocols in end-stage NOD mice.
