Has the genetic activity of neural crest cells during the developmental process been catalogued?
We’re getting there. With the full genetic complement, or genomes, of various species now determined, the rate of identifying genes involved in making a head or a heart has increased exponentially. It’s left us wading through a huge amount of data. That’s exciting in that so many more pieces to the puzzle are spread out on the table. The problem is this heavy volume makes assembling the puzzle more complex. If I’m dealing with 500 or 1,000 genes to figure out how they work together to create a cell type or render a neural crest cell migratory, I might be really puzzled. If I have a colleague who is looking at it from an opposite approach but happens to identify a subset of those genes, we can take those 1,000 candidate genes and cut them to 10 and begin thinking about communication nodes and signaling networks. What I’m hoping is that by putting these groups together, we can narrow down the key players more quickly. There’s going to be common themes running through this. Unless you do
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