Has it been looked to be sure theres not a gradient over the back and erythema?
DR. SLATER: We actually didn’t always start at the top. In the example that I showed, just for simplicity of showing it, we started at the top. The actual protocol called for sort of going back and forth starting. We always started on one end and worked to the other. But we didn’t always start on the top. That was randomized. Dr. Granady? DR. GRANADY: Can you comment on using the erythema versus the wheal size? DR. SLATER: I can. It’s for statistical reasons. The line that you get — and you can think this through sort of intuitively. The line that you tend to get with the wheal size tends to be much flatter. And therefore, smaller errors in measurement lead to greater errors in the calculation of the D50. So when these studies were initially done I understand. The original papers on this were from the 1970s. When this was originally done, they did both with sigma E and sigma W for wheal size. And you can get valid data both ways. But the error of the measurement is greater with the wh
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