For the approved and off-label indications for chlorothiazide, is a loop diuretic a suitable alternative?
Parenteral loop diuretics and parenteral chlorothiazide can be used for edema associated with heart failure, hepatic cirrhosis, chronic renal failure, glomerulonephritis, or nephrotic syndrome.2 Thiazides are considered relatively weak diuretics and are therefore rarely used alone in heart failure; however, they may be used in patients with mild fluid retention.3,4 Loop diuretics are the chief diuretic class used in the treatment of heart failure. In disease states such as renal failure, glomerulonephritis, and nephrotic syndrome, loop diuretics are the drugs of choice in management of the associated edema.
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