During what timeframe should Rh (D) immunoglobulin be administered after a potentially sensitising event for successful immunoprophylaxis?
For successful immunoprophylaxis, Rh (D) immunoglobulin should be administered as soon as possible after the sensitising event, but always within 72 hours. Blood should be taken from the mother before administration of the Rh (D) immunoglobulin to assess the magnitude of fetomaternal haemorrhage FMH. Where FMH quantitation shows that FMH greater than that covered by the dose already administered has occurred, administration of an additional dose(s) sufficient to provide immunoprophylaxis must be administered and preferably within 72 hours. Assessment of FMH by Kleihauer testing is generally not indicated in the first or second trimesters. If Rh (D) immunoglobulin has not been offered within 72 hours, a dose offered within up to 9-10 days may provide protection. During the informed consent process the patient should be advised of the potential consequences of the delay in the administration of Rh (D) immunoglobulin and consideration be given to insurer notification.
Related Questions
- If Rh (D) immunoglobulin is given for a sensitising event, is it still necessary to give Rh (D) immunoglobulin prophylactically at 28 and 34 weeks?
- During what timeframe should Rh (D) immunoglobulin be administered after a potentially sensitising event for successful immunoprophylaxis?
- If Rh (D) immunoglobulin is given for a sensitising event, is it still necessary to give Rh (D) immunoglobulin prophylactically postnatally?
