Drug Interaction Question: Could you send me all of the serious side effects of the following four drugs taken together: phentermfine, zoloft, depakote and pondimin?
There is no published data on multiple drug interaction. The best that can be done is to extrapolate the side effects and toxicities– the actual interaction between four is not able to be predicted. However, phenteramine and pondimin should not be taken with Zoloft or any other SRI antidepressant. This is due to the simultaneous effect on serotonin in the body by both drugs. Depakoke’s common side effects include nausea, sleepiness, vertigo(dizziness). Zoloft tends to produce constipation, headaches, drowsiness, and urinary hesitation. Phenteramine andpondimin tend to produce dry mouth, constipation, sleepiness– so I would think sleepiness and constipation might be fairly severe. Again, Zoloft is strictly not to be used with the combination of pondimin and phenteramine.
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