Does voided urine cytology have biological significance?
Tut VM; Hildreth AJ; Kumar M; Mellon JK Department of Urology, University of Newcastle upon Tyne, Newcastle, UK. OBJECTIVE: To (i) define any correlation between the result of voided urine cytology (VUC) at presentation and the biological behaviour of Ta/T1 transitional cell carcinoma (TCC) of the bladder; and (ii) observe the natural history of Ta/T1 bladder cancer in relation to new prognostic groupings. PATIENTS AND METHODS: The study comprised 109 patients with newly diagnosed Ta/T1 TCC of the bladder, all of whom had VUC assessed at presentation. Information on the number of tumours at presentation and the subsequent tumour recurrence rate during clinical follow-up was compared with the outcome of VUC. RESULTS: Of the 109 patients, 67 (61%) had Ta and 42 (39%) had T1 tumours. At presentation, there were 75 (69%) solitary (Ta=50, T1=25) and 34 (31%) multifocal (Ta=17, T1=17) tumours. At presentation, VUC was negative in 71 (65%), suspicious in 22 (20%) and positive for urothelial c
