Does VENDYS temperature rebound (TR) change in the presence of nitric oxide (NO) inhibitors?
A6. Studies have shown that cutaneous microvascular reactivity, measured by laser Doppler flowmetry (LDF, the current, standard method of measuring skin blood flow), is blunted by NO synthase inhibitors. Similar studies using VENDYS are underway. These studies not only investigate the effect of an eNOS (endothelial NO synthase) inhibitor on fingertip temperature reactivity in the occluded arm, but also aim to test the hypothesis that increased temperature in the contralateral finger during cuff occlusion is partly effected by eNOS and nNOS (neuronal NO synthase).
