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Does this study address an important problem broadly related to cardiovascular disease or stroke?

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Does this study address an important problem broadly related to cardiovascular disease or stroke?

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10

What will be the effect of these studies on the concepts, methods and technologies that drive this field? • Approach: A new fellow may not have had adequate time to generate preliminary data. Applicants can present preliminary data generated by the sponsor. The assessment of preliminary data, whether generated by the sponsor or the applicant, should be put into perspective so that bold new ideas and risk taking by beginning investigators are encouraged rather than stymied. Are the conceptual framework, design, methods and analyses adequately developed, well integrated, well reasoned, feasible (as determined by preliminary data or the expertise available in the mentor’s and/or collaborator’s laboratories) and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics? • Innovation: Is the project original? Applicants should never contact reviewers regarding their applications. Discussing scientific content of an applic

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