Does the vaginal use of oral misoprostol tablets in medical abortion cause infection?
FDA has no evidence that vaginal use of misoprostol causes infection. The companies making misoprostol tablets have performed and met the usual quality control tests for marketing misoprostol oral tablets. 6. Has any causal relationship between these events and the use of Mifeprex and misoprostol been established? No. The FDA will continue to evaluate all case reports and other information to determine if there is any causal relationship. 7. Should women undergoing medical abortion be getting antibiotics to prevent fatal infections? At this time FDA does not have sufficient information to recommend the use of preventive antibiotics for all women undergoing medical abortion. Reports of fatal sepsis in women undergoing medical abortion are very rare (1 in 100,000). Preventive antibiotic use carries its own risk of serious adverse events such as severe or fatal allergic reactions. Also, preventive use of antibiotics can stimulate the growth of “superbugs,” bacteria resistant to everyday a
