Does the Supplemental Guidance address all potential carcinogens?
The Supplemental Guidance recommends consideration of all studies on the effects of early-life exposures. For the common case where there are no early-life studies on a potential carcinogen, the final Guidelines suggest consideration of the carcinogen’s mode of action. The Supplemental Guidance addresses carcinogens with a mutagenic mode of action in detail because currently most early-life studies are for carcinogens with a mutagenic mode of action. As new research leads to more conclusive evidence, EPA intends to update this guidance to address other modes of action.
