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Does the saturable component only make a difference at intakes greater than 100 micrograms per day (g/day)?

April 26, 2017component greater intakes micrograms saturable

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Does the saturable component only make a difference at intakes greater than 100 micrograms per day (g/day)?

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The non-linearity observed in the intake/uptake relationship from the IEUBK model may be more obvious at higher intake rates (i.e., 100 g/day or more), but this is only because the equation for a rectangular hyperbola defines the observed curve. At low doses, the relationship is still non-linear, but it is not as obvious.