Does the Resistance Gene in SR/CR Mice Work Against Other Types of Tumor?
An important initial question in studying these mice was whether the resistance to cancer only worked against this unusual tumor type (S180 sarcoma), or would work against other types of cancer. Using several different mouse cancer types, such as leukemia, lymphoma, liver cancer, and lung cancer, it was shown that the SR/CR mouse was resistant to all of them. Further, other experiments were done to show that, in addition to tumors in the abdominal cavity, tumors that grow in other sites, such as under the skin, were also rejected by this mouse. What Happens to the Tumor Cells Injected into these Resistant Mice? Because the initial experiments used tumor cells that were transplanted by injection into the abdominal cavity of mice, the injected cells could be recovered at a later time and examined. It was also possible to see if other cell types from the resistant mouse were interacting with the tumor cells directly. When this was done, it was found that injected cancer cells in these mic
