Does the prognostic value of troponin for mortality or myocardial infarction differ between men and women?
We performed standardized searches of electronic databases of publications relevant to the topic areas. We developed specific search terms for each of the four key topics and conducted a separate search for evidence regarding each. We also reviewed the bibliographies of retrieved articles and sought suggestions for additional articles from our expert peer reviewers. For each topic area, we established clear inclusion criteria that required that studies provide data regarding the research question specific to women. For three of the key questions (noninvasive diagnostic tests, lipid lowering and diabetes), two UCSF-Stanford EPC investigators reviewed all identified titles and excluded those that did not meet inclusion criteria. The abstracts of remaining articles were reviewed by two UCSF-Stanford EPC physician investigators, who independently classified eligibility. The full text of the remaining eligible articles was reviewed independently by two UCSF-Stanford EPC physician investigat
