Does the pro-inflammatory factor in lymphocytes (LpIF) explain the role of these cells in acute inflammation?
Lymphocytes produce a pro-inflammatory factor, which modulates the development of acute inflammation. Injection of lymphocytes or products, obtained from either rats, dogs or rabbits, caused a restoration of inflammatory responses in leukopenic rats which are hyporeactive to various inflammatory stimuli. In vitro incubation of viable lymphocytes with homologous and heterologous anti-lymphocyte sera abolished the ability of the cells to restore the inhibited inflammatory reactions.
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