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Does the new operational definition of cachexia (ODC) help with profiling nutrition and performance characteristics in advanced cancer patients?

April 26, 2017cachexia characteristics definition help nutrition ODC operational PERFORMANCE profiling

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Does the new operational definition of cachexia (ODC) help with profiling nutrition and performance characteristics in advanced cancer patients?

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Antonio AL Vigano1, Enriqueta Lucar1, Mariana Sanguineti1, Barbara Trutschnigg1, Haneen Molla1, Celena Sheede-Bergdahl 1,2, Robert D. Kilgour1,2 1McGill Nutrition and Performance Laboratory, McGill University Health Centre (MUHC); 2Department of Exercise Science, Concordia University; Montreal, Quebec, Canada. Background & Aims: To compare the use of the ODC (Evans, 2008) with the recording of weight loss (WL) for profiling nutrition and performance characteristics of advanced cancer patients (ACP). Methods: 214 newly diagnosed ACP with non-small cell lung and gastrointestinal primaries were categorized as cachectic according to the ODC [cachexia = WL ≥5% over ≤ 12 months (or BMI <20) plus ≥ 3/5 criteria including decreased muscle strength (hand-grip), fatigue (≥3/10 on ESAS), anorexia (≥3/10 on ESAS), sarcopenia by DXA and abnormal biochemistry (CRP >5.0 mg/l or IL-6 >4.0pg/ml or Hgb <12g/dl or albumin <3.2 g/l)] or as weight losing if they had >5% WL over ≤ 6 months.