Does the neuropeptide somatostatin have therapeutic potential against schistosomiasis?
Chatterjee S; Mbaye A; De Man JG; Van Marck EA Pathology Unit, Dept of Medicine, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. shyama@uia.ua.ac.be The neuropeptide hormone somatostatin is used to treat bleeding oesophageal varices and to reduce portal pressure, and can prevent progression to severe fibrosis in chronic liver disease. We believe that somatostatin can also have therapeutic potential against schistosomiasis, based on recent observations that severe morbidity symptoms are associated with low levels of host somatostatin in patients infected with Schistosoma mansoni. The administration of exogenous doses of this neuropeptide could therefore alleviate the pathology caused by schistosomiasis.
