Does the nature of the solvent affect the anti-inflammatory capacity of triclosan?
Author(s): Skaare AB, Kjaerheim V, Barkvoll P, Rolla G Affiliation(s): Department of, Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Norway. Publication date & source: 1997-02, J Clin Periodontol., 24(2):124-8. Publication type: Clinical Trial; Randomized Controlled Trial The anti-inflammatory properties of triclosan have been revealed in several recent studies, including an effect on histamine-induced inflammation. In other studies, the nature of the solvent has been shown to be of importance for the plaque inhibiting as well as the antibacterial potential of triclosan. This study was aimed at examining whether the nature of the solvent also may influence the anti-inflammatory capacity of triclosan and further to study a possible dose/ response relationship. The study was performed as 3 separate, double-blind experiments, comprising 10, 11 and 12 healthy females. In all 3 experiments, 5 sites on the lower part of the back of the volunteers were intradermally
