Does the HPV vaccine have therapeutic activity?
No. The quadrivalent HPV vaccine is purely prophylactic and does not alter the natural history of an ongoing HPV infection. To ensure maximal benefit of HPV immunization, females must be immunized prior to acquisition of any HPV infection, ideally prior to sexual debut. 6. Do vaccinated women still need routine Pap smears? Yes. Because the vaccine contains antigens for HPV 16 and 18, but not for other oncogenic HPV types, it can prevent up to 70% of cervical cancers. Therefore, cervical cytology screening will remain a vital part of women’s health care, even in women fully immunized against HPV. 7. Can the vaccine be given to women on hormonal contraceptives? Yes. In clinical studies, use of hormonal contraceptives did not affect vaccine efficacy. 8. Can the HPV vaccine be given with other vaccines? Yes. The ACIP suggests that the HPV vaccine can be given with other vaccines. † 9. Why is the vaccine approved only for females ages 9 to 26? The safety and efficacy of the vaccine has not
