Does the chromosome 22q11.2 deletion run in families?
Most cases occur at random and aren’t inherited or related to any identifiable cause. However, approximately 5 to 10 percent of children with a chromosome 22q11.2 deletion inherit it from a parent who has a mild, usually undiagnosed, form. Because the disorder is so variable, even people from the same family, with the same deletion, may have very different kinds of problems. When one parent has a chromosome 22q11.2 deletion, the chance of passing this disorder on to a child is one in two, or 50 percent, with each pregnancy.
