Does the ambient temperature or the body temperature play a role in EIC?
Dogs that collapse with EIC, as well as normal dogs after similar exercise, have a temperature of 106-108 F. We believe it is possible that the activity of the E form of the protein may be further diminished by the elevated body temperatures that usually develop during exercise itself. Evidence that DNM1 mutations cause temperature sensitive alterations in dynamin 1 function, resulting in neurological and neuromuscular defects are found in other organisms, including fruit flies (Drosophila melanogaster), and worms (C elegans). While dogs can collapse under any temperature and humidity conditions, it has been found that higher than normal temperature and humidity can make a collapsing event more likely to occur.
