Does substitution of T4 with T3 plus T4 for T4 replacement improve depressive symptoms in patients with hypothyroidism?
Joffe RT; Sawka AM; Marriott MJ; MacQueen GM; Gernstein HC Department of Psychiatry, UMDNJ, New Jersey Medical School, Newark, NJ 07103, USA. joffe@umdnj.edu Substitution of T4 with T3 for T4 replacement in patients with hypothyroidism was undertaken using a randomized placebo controlled study design. Forty individuals were included who had depressive symptoms on stable doses of levothyroxine. Combined T4 plus T3 did not have a significantly different effect on mood and well-being scores than did T4 alone.
