Does Spontaneous Ca2+ Release Play a Role in VF Dynamics?
Intracellular calcium overload-induced spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) causes afterdepolarizations which can trigger action potentials and ectopic arrhythmias.15 In ferret hearts perfused with crystalline solution, pacing induced VF lead to a rapid and marked increase in Cai.36 Others demonstrated that manipulations leading to Cai overload readily induced VF.37,38 Those studies, however, did not provide definitive data as to the role of Cai oscillations in the maintenance of VF (this topic is discussed in Ref. 14). A number of computational studies suggested a possibility for a significant contribution of spontaneous SR Ca2+ release secondary to Ca2+ overload into the destabilization of spiral waves either during the initiation or maintenance of VF, depending on certain parameters of Cai formulations used in those studies.13,14,39,40 On the experimental side, Omichi et al14 speculated that “the failure of Cai to faithfully track Vm during VF might be expla
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