Does specific brain structure involvement predict AFQT score or change in AFQT?
A stepwise regression analysis was performed to look for predictors of current AFQT and change in AFQT over all phases. The dependent variables included current AFQT scores, right hemisphere volume loss (judged by V.R. and J.G. to be specific to the initial lesion, rather than additional atrophy) left hemisphere volume loss, change in total volume loss from P2 to P3, three measurements of corpus callosum width, involvement of the following brain structures: caudate, substantia nigra, globus pallidus, white matter, thalamus, hippocampus and the specific lateral and overall involvement of the following regions of the cortex: the frontal, parietal, temporal and occipital lobes, as well as the insula and amygdala. Hence, these measurements focused on differences in location of the primary lesion, rather than any subsequent atrophic change. Lesions in the caudate nucleus (t = –5.623, P < 0.001), left parietal lobe (t = –3.225, P = 0.002), right amygdala (t = 2.241, P = 0.026), hippocampus (
