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Does primary myelofibrosis involve a defective stem cell niche?

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Does primary myelofibrosis involve a defective stem cell niche?

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Jean-Jacques Lataillade1, Olivier Pierre-Louis2,3, Hans Carl Hasselbalch4, Georges Uzan2,3, Claude Jasmin2,3, Marie-Claire Martyré2,3, Marie-Caroline Le Bousse-Kerdilès2,3, on behalf of the French INSERM and the European EUMNET Networks on Myelofibrosis 1 Laboratoire de Recherche, Center de Transfusion Sanguine des Armeés (CTSA), Hôpital Percy, Clamart, France; 2 INSERM U602, Hôpital Paul Brousse, Villejuif, France; 3 Université Paris 11, Institut Fédératif de Recherche (IFR) 89, Institut André Lwoff, Villejuif, France; and 4 Department of Hematology, Herlev University Hospital, Copenhagen, Denmark

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