Does poor oxygenation during one-lung ventilation impair aerobic myocardial metabolism in patients with symptomatic coronary artery disease?
One-lung ventilation is used during a variety of surgical procedures, even in patients with pre-existing coronary artery disease. The study purpose was to elucidate if myocardial metabolism crosses the anaerobic threshold under hypoxemia during one-lung ventilation. Therefore, we determined myocardial metabolism as a marker for anaerobic myocardial metabolism in patients with significant multi-vessel coronary artery disease undergoing one-lung ventilation during minimally-invasive coronary artery bypass grafting. Twenty patients with multi-vessel coronary artery disease underwent minimally-invasive revascularisation on cardiopulmonary bypass. One-lung ventilation was used for at least 45 min prior to cardiopulmonary bypass. Blood samples were drawn from arterial and coronary sinus blood at various times throughout the procedure to determine myocardial metabolism. After institution of one-lung ventilation arterial partial pressure of oxygen decreased significantly, down to levels betwee
Related Questions
- Does poor oxygenation during one-lung ventilation impair aerobic myocardial metabolism in patients with symptomatic coronary artery disease?
- Is septal glucose metabolism altered in patients with left bundle branch block and ischemic cardiomyopathy?
- Are there facilities for non-English/poor English speaking patients?
