Does polio vaccine being given in the U.S. today contain SV40?
No, polio vaccines being used today do not contain SV40. • SV40 was completely removed from the seed strains of the vaccine viruses in the early 1960s. • The polio vaccine currently used in the U.S. (inactivated polio vaccine, or IPV) is no longer prepared in primary rhesus monkey kidney cells. It is produced in human or African green monkey cell lines that have been extensively tested for contaminants, including SV40. • The poliovirus used in IPV is killed with formaldehyde. This procedure also kills viral contaminants, such as SV40. Formaldehyde was also used in the SV40-contaminated vaccine, but in 1961 researchers found that the process killed 99.99% of SV40 and 1 in 10,000 SV40 particles survived (Hilleman, 1998). • Todays testing methods are better. Any live SV40 would be detected by these methods. Top • What about concerns that the testing methods used to screen oral polio vaccines could have missed certain strains of SV40? Oral polio vaccine (OPV, which is no longer recommended
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- Does polio vaccine being given in the U.S. today contain SV40?
