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Yes, Photomatix Pro and Photomatix Light work fine with the 64-bit edition of Windows XP, Vista and 7, and work fine on 64-bit Mac OS. Moreover, Photomatix Pro for Windows is available as 64-bit edition and Photomatix Pro and Photomatix Light for Mac OS X are 32/64-bit Universal, and thus take advantage of the 64-bit capability of your OS.
