Does Pethidine and/or Local Anaesthetic Solution in the Abdominal Cavity Reduce Pain after “Key-Hole” Surgery?
We have just completed a 3-year study designed to determine whether pethidine, with or without local anaesthetic, relieves pain after major “key-hole” surgery, when instilled into the abdominal cavity at the end of a laparoscopic operation. Instilling local anaesthetic has a beneficial effect on pain after minor laparoscopic surgery, for example sterilisation. Pethidine might work because it is absorbed into the blood (thus being similar to the effect achieved after an injection into a muscle or intravenous “drip”) or by acting as a local anaesthetic on the operated area. We studied 220 patients having either laparoscopic cholecystectomy at Royal Perth Hospital or major pelvic gynaecological laparoscopy at King Edward Memorial Hospital. They received a solution into the abdominal cavity at the completion of surgery, that contained either pethidine (two different doses), local anaesthetic, both, or a placebo (these patients also received an injection of pethidine). Unfortunately, in con
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