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Whether you have been exposed to a chest x-ray, an infection, a chemical, or a drug during pregnancy you may find some comfort in the knowing that the majority of such exposures do not result in birth defects or other risks to the fetus. Nonetheless, you should be aware that most drugs cross the placenta, and that there is little information about the first-trimester effects for many drugs in human pregnancy. Therefore make sure to ask your doctor before starting a medication during pregnancy. Also make sure to ask your doctor before you stop taking a medication such as levothyroxine (Synthroid®, Levoxyl®) or insulin, since untreated illnesses can have a harmful effect on your pregnancy. Medications and Potential Teratogens in Pregnancy An agent that causes a birth defect to occur at a higher rate than expected is called a teratogen. The agent may be a chemical, a drug, an infection, radiation, or a maternal condition such as diabetes. It is often difficult to determine whether a bad o