Does p53 control centrosome duplication directly or indirectly?
Since p53 is also involved in DNA repair and checkpoint response to genotoxic as well as physiological stress (for reviews, see Ko and Prives, 1996; Mowat, 1998), loss of p53 is expected to result in an increased frequency of genetic mutations. Thus, it is possible that loss of p53 leads to secondary mutations of other genes, whose products are the direct regulators of the centrosome duplication cycle. In this setting, loss of p53 indirectly induces centrosome hyperamplification. In contrast, p53 may be directly and actively involved in the regulation of centrosome duplication. If the former possibility is correct, re-introduction of wild-type p53 into p53-/- cells should not restore the centrosome duplication cycle, since the secondary mutation(s) continue to exist. On the other hand, if the latter possibility is correct, the centrosome duplication cycle of p53-/- cells should be restored by re-introduction of wild-type p53. When wild-type p53 was re-introduced at a physiological leve
Related Questions
- How can companies take advantage and participate, directly or indirectly, in the TRLabs Disruptive Technology Challenge?
- What kinds of injuries are seen in golf that are caused directly or indirectly by foot function?
- What kinds of injuries are seen in golf that are caused directly or indirectly by foot function?
- Does attention control directly enter into visual working memory?
- Does attention control directly enter into visual working memory?
- Does p53 control centrosome duplication directly or indirectly?
