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Does olanzapine-fluoxetine combination increase the risk of mania in poorly compliant bipolar depressed patients?

April 26, 2017bipolar combination compliant depressed increase Mania Patients poorly risk

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Does olanzapine-fluoxetine combination increase the risk of mania in poorly compliant bipolar depressed patients?

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and acute bipolar mania. In 2001, olanzapine-fluoxetine combination was found to be effective in a small sample of patients with nonbipolar depression. (1) Subsequently, a controlled study demonstrated olanzapine to be more effective than placebo and olanzapine plus fluoxetine more effective than olanzapine plus placebo for treatment of bipolar depression, without significant risk of development of mania. (2) We describe a patient with bipolar depression with development of mania related to treatment with olanzapine-fluoxetine combination.