Does myocardial constitutive NO production modulate β-adrenergic contraction and its inhibition by CCh?
Fig. 1 Role of nNOS on β-adrenergic and cholinergic inotropic responses in isolated LV myocytes. A: Examples of sarcomere shortening under basal conditions, in the presence of ISO (100 nmol/L), ISO+CCh (1 µmol/L) and after wash-out in LV myocytes from nNOS– / – mice and their wild type littermates (nNOS+/+) field-stimulated at 1 Hz. B: Average percent sarcomere shortening in LV myocytes from nNOS– / – and nNOS+/+. Note that shortening is significantly greater in nNOS– / – myocytes at all stages of the experimental protocol (*P<0.05 vs. nNOS+/+, n=37 cells per group).
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