Does multiple myeloma produce monoclonal gammapathy or polyclonal gammapathy?
multiple myeloma causes monoclonal gammapathy. gammopathy abnormal proliferation of the B lymphocytes resulting in abnormal levels of immunoglobulin production; the gammopathies include multiple myeloma, macroglobulinemia and Hodgkin’s disease. Called also gammaglobulinopathy. monoclonal gammopathy an increased production of one type of immunoglobulin by a single clone of cells. The abnormal protein produced is called paraprotein or M component and may be composed of whole immunoglobulin molecules or subunits, light-chains (Bence Jones proteins) or heavy-chains. Occurs in myelomas, lymphoproliferative neoplasms, and occasionally chronic inflammatory or immune-mediated diseases. Greatly elevated serum levels of protein may result in a hyperviscosity syndrome. polyclonal gammopathy a hypergammaglobulinemia resulting from an increased production of several different immunoglobulins and usually attributable to persistent, high level exposure to antigens; occur in a wide variety of infectio
