Does Micronization of Trans-resveratrol Improve Bioavailability?
There is no published data to support enhanced bioavailability of resveratrol through micronization. In fact quite the opposite is true. Micronization is being touted by some suppliers even though the data shows that it actually decreases total resveratrol absorption. It is true that some drugs and nutrients are enhanced by micronization however resveratrol is not one of them. Furthermore, once a micronized powder is packed into a capsule it aggregates within a short time due to the pressure and moisture and no longer is micronized. Biotivia has studied the issue of particle size in relation to free resveratrol and resveratrol metabolite bioavailability. Our conclusion, and that of other bio chemists, is that at a particle size of between 1 and 10 nanometers (micronized) a graph of blood plasma levels vs. time shows an initial spike of resveratrol concentration but one which is no higher than the maximum amplitude of the concentration curve shown with resveratrol particles of 200nm (no
