Does lentivirus exhibit the same toxicity as adenovirus in vivo?
It is known for fact that lentiviruses transduce cells with the higher efficiency and toxicity effect is lowered by presence of VSV-G-pseudotyped envelope. However, toxicity will vary on a case-by-case basis. Advantage of Lentiviral vectors is that they appear to be able to mediate persistent in vivo expression in a host of different cell types. However, the duration of expression in the context of a human clinical trial has not yet been determined. The disadvantages of adenoviral vectors is that they can mediate robust expression in some cells and that expression is transient, due in part to the inflammation and cell-mediated immune response directed against the transduced cells.
