Does impaired transcellular water transport contribute to net ultrafiltration failure during CAPD?
OBJECTIVES: To assess the contribution of transcellular water transport in net ultrafiltration failure during continuous ambulatory peritoneal dialysis (CAPD). DESIGN: Retrospective. SETTING: Renal Unit, Academic Medical Center, Amsterdam. PATIENTS: One group of 6 patients with clinical severe ultrafiltration loss and a group of 10 stable CAPD patients without ultrafiltration problems. INTERVENTION: In all patients, two peritoneal permeability tests were done within one week, using glucose 1.36% dialysate on one day and glucose 3.86% on the other day. Dextran 70 was used as a volume marker. RESULTS: The difference in net ultrafiltration between 3.86% glucose and 1.36% glucose dialysate was 569 +/- 51 mL (control) and 153 +/- 103 mL (poor ultrafiltration group; p < 0.005). The dialysate/plasma (D/P) concentration ratios increased in both groups with glucose 1.36%. When using 3.86% glucose, the D/P ratio decreased in the control group with a median minimum value one hour after completion
