Does hippocampal neurogenesis matter?
Dr. Barlow: We believe it does. Of course, we are just beginning to understand the relevance of neurogenesis in the clinical realm. Actually, the hippocampus is in a unique position to influence and be influenced by multiple brain areas that are associated with mood and cognition. Some recent studies have suggested that neurogenesis in the ventral portion of the hippocampus is associated with emotional behavior.[3] Remarkably, it has been demonstrated that every commercially available antidepressant is neurogenic, and that some putative antidepressants that have failed to be approved were not neurogenic.[4,5] Furthermore, using mouse models, Rene Hen at Columbia University has shown that knocking out neurogenesis actually blocks antidepressant action.[5] How can this knowledge about neurogenesis help with new drug discovery? Dr. Barlow: Based upon our hypothesis that hippocampal neurogenesis is a necessary factor for successful antidepressant activity, we believe we can find new drugs
