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Does high-dose allopurinol prevent post-ERCP pancreatitis?

April 26, 2017allopurinol high-dose pancreatitis post-ercp

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Does high-dose allopurinol prevent post-ERCP pancreatitis?

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Original article Katsinelos P et al. (2005) High-dose allopurinol for prevention of post-ERCP pancreatitis: a prospective randomized double-blind controlled trial. Gastrointest Endosc 61: 407–415 PubMedAllopurinol inhibits the generation of oxygen-derived free radicals and it has been postulated that this xanthine oxidase inhibitor might prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis.